An Unusual (R)-Selective Epoxide Hydrolase with High Activity for Facile Preparation of Enantiopure Glycidyl Ethers

@inproceedings{Zhao2011AnU,
  title={An Unusual (R)-Selective Epoxide Hydrolase with High Activity for Facile Preparation of Enantiopure Glycidyl Ethers},
  author={Jing Feng Zhao and Yan-Yan Chu and Li Aitao and Xin Yao Ju and Xu-Dong Kong and Jiang Qiong Pan and Yun Tang and Jian-he Xu},
  year={2011}
}
A novel epoxide hydrolase (BMEH) with unusual (R)-enantioselectivity and very high activity was cloned from Bacillus megaterium ECU1001. Highest enantioselectivities (E > 200) were achieved in the bioresolution of ortho-substituted phenyl gly- cidyl ethers and para-nitrostyrene oxide. Worthy of note is that the substrate structure remarkably affect- ed the enantioselectivities of the enzyme, as a re- versed (S)-enantiopreference was unexpectedly ob- served for the ortho-nitrophenyl glycidyl… CONTINUE READING

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