An Under-Recognized Benefit of Cardiopulmonary Resuscitation: Organ Transplantation*

  title={An Under-Recognized Benefit of Cardiopulmonary Resuscitation: Organ Transplantation*},
  author={Alberto Orioles and Wynne Ellen Morrison and Joseph W. Rossano and Paul M. Shore and Richard Hasz and Amy C Martiner and Robert A. Berg and Vinay M. Nadkarni},
  journal={Critical Care Medicine},
Objective:For many patients who suffer cardiac arrest, cardiopulmonary resuscitation does not result in long-term survival. For some of these patients, the evolution to donation of organs becomes an option. Organ transplantation after cardiopulmonary resuscitation is not reported as an outcome of cardiopulmonary resuscitation and is therefore overlooked. We sought to determine the number and proportion of organs transplanted from donors who received cardiopulmonary resuscitation after a cardiac… 

Cardiopulmonary resuscitation: saving life then saving organs?

The message for critical care practitioners is that despite the theoretical potential to worsen ischemic organ injury, the provision of CPR does not necessarily preclude organ donation or impair transplant graft function, and should encourage clinicians to attempt CPR with the goal of preserving the opportunity for organ donation.

Impact of donor cardiopulmonary resuscitation on the outcome of simultaneous pancreas–kidney transplantation—a retrospective study

It is indicated that post‐CPR brain‐dead donors are suitable for PT without increasing the risk of complications, and no statistically significant association between donor CPR and patient or graft survival is suggested.

Cardiopulmonary Resuscitation Maneuvers in the Organ and Tissue Donor Patient

The scientific evidence postulates mainly a benefit of the cardiopulmonary resuscitation maneuvers in the donor patient, without involvement in the organs because it increases their Blood perfusion and their oxygenation.

Organ donation after out-of-hospital cardiac arrest: a population-based study of data from the Paris Sudden Death Expertise Center

Patients with OHCA constitute a valuable source of donated organs, and special attention should be paid to young patients withOHCA of neurological cause.

Cardio‐pulmonary resuscitation of brain‐dead organ donors: a literature review and suggestions for practice

It is concluded that OP‐CPR can benefit patients and families by fulfilling the wish to donate, however, it is an aggressive procedure that can cause physical damage to patients, and risks psychological harm to families and healthcare professionals.

The rate of brain death and organ donation in patients resuscitated from cardiac arrest: a systematic review and meta-analysis

In patients with hypoxic-ischaemic brain injury following CPR, more than 10% of deaths were due to brain death, and more than 40 % of brain-dead patients could donate organs, suggesting patients who are unconscious after resuscitation from cardiac arrest, especially when resuscitated using e-CPR, should be carefully screened for signs of brain death.

Brain-Dead Donors on Extracorporeal Membrane Oxygenation*

Brain-dead patients with ongoing extracorporeal membrane oxygenation are suitable for organ procurement, and they have more severe medical conditions than those without extracorporation, according to a retrospective analysis of the national information system.

Treating the donor

Care of patients with catastrophic brain injury incorporating supportive therapy targeted at specific goals and delivered by experienced specialists provides the best donation outcomes and pathways represent best practice critical care applied to this population.

A simplified preservation method for lungs donated after cardiac death.




Utilization of Donors Who have Suffered Cardiopulmonary Arrest and Resuscitation in Intestinal Transplantation

A donor history of cardiac arrest should not automatically exclude the use of the intestine graft for transplantation, and outcome parameters such as operative time, blood use, ventilation days, length of stay, time to enteral independence, rejection, enteric bacteremia, and survival are not significant.

Use of donors who have suffered cardiopulmonary arrest and resuscitation in lung transplantation.

  • K. PilarczykB. Osswald M. Kamler
  • Medicine
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2011

Donors with cardiac arrest: improved organ recovery but no preconditioning benefit in liver allografts

Compared with historical data, cardiovascular stability and abdominal organ recovery rates have improved considerably in CA donors, and posttransplantation graft function and injury parameters were similar between the two groups, and CA did not appear to trigger IP.

Pediatric transplantation using hearts refused on the basis of donor quality.

An underrecognized source of organ donors: patients with brain death after successfully resuscitated cardiac arrest

Brain death may occur in about one-sixth of patients after successfully resuscitated out-of-hospital cardiac arrest, creating opportunities for organ donation.

Influence of donor cardiopulmonary arrest in human liver transplantation: Possible role of ischemic preconditioning

Although the liver function tests are elevated in an organ donor, the hepatic allograft is suitable for OLT if the liver damage is induced by brief donor cardiopulmonary arrest, and Experiences of brief cardiopULmonary arrest in organ donors did not affect post‐OLT hepaticAllograft survival and function.

Utilization of pediatric donors salvaged by cardiopulmonary resuscitation.

Although donors with a history of protracted CPR had higher efflux of myosin light chains perioperatively, hemodynamic recovery suggests that use of pediatric donor heart grafts after prolonged CPR is safe and efficacious.

A systematic review of kidney transplantation from expanded criteria donors.

ECD kidneys have worse long-term survival than standard criteria donor kidneys and patients younger than 40 years or scheduled for kidney retransplantation should not receive an ECD kidney, based on the available evidence.