An Unconventional Mechanistic Insight into SCF3 Formation from Difluorocarbene: Preparation of 18 F-Labeled α-SCF3 Carbonyl Compounds.

@article{Zheng2017AnUM,
  title={An Unconventional Mechanistic Insight into SCF3 Formation from Difluorocarbene: Preparation of 18 F-Labeled α-SCF3 Carbonyl Compounds.},
  author={Jian Zheng and Ran Cheng and Jin-Hong Lin and Dong-Hai Yu and Longle Ma and Lina Jia and Lan Zhang and Lu Wang and Ji-Chang Xiao and Steven H. Liang},
  journal={Angewandte Chemie},
  year={2017},
  volume={56 12},
  pages={3196-3200}
}
Trifluoromethylthiolation by sulfuration of difluorocarbene with elemental sulfur is described for the first time, which overrides long-standing trifluoromethyl anion-based theory. Mechanistic elucidation reveals an unprecedented chemical process for the formation of thiocarbonyl fluoride and also enables transition-metal-mediated trifluoromethylthiolation and [18 F]trifluoromethylthiolation of α-bromo carbonyl compounds with broad substrate scope and compatibility.