An Ultrasensitive Mechanism Regulates Influenza Virus-Induced Inflammation

  title={An Ultrasensitive Mechanism Regulates Influenza Virus-Induced Inflammation},
  author={Jason E. Shoemaker and Satoshi Fukuyama and Amie J. Eisfeld and Dongming Zhao and Eiryo Kawakami and Saori Sakabe and Tadashi Maemura and Takeo Gorai and Hiroaki Katsura and Yukiko Muramoto and Shinji Watanabe and Tokiko Watanabe and Ken Fuji and Yukiko Matsuoka and Hiroaki Kitano and Yoshihiro Kawaoka and Se{\'a}n O. Whelan},
  booktitle={PLoS pathogens},
Influenza viruses present major challenges to public health, evident by the 2009 influenza pandemic. Highly pathogenic influenza virus infections generally coincide with early, high levels of inflammatory cytokines that some studies have suggested may be regulated in a strain-dependent manner. However, a comprehensive characterization of the complex dynamics of the inflammatory response induced by virulent influenza strains is lacking. Here, we applied gene co-expression and nonlinear… CONTINUE READING
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