An Ultra High-Throughput, Whole-Animal Screen for Small Molecule Modulators of a Specific Genetic Pathway in Caenorhabditis elegans

@inproceedings{Leung2013AnUH,
  title={An Ultra High-Throughput, Whole-Animal Screen for Small Molecule Modulators of a Specific Genetic Pathway in Caenorhabditis elegans},
  author={C. K. Leung and Ying Wang and Siobhan Malany and Andrew S. Deonarine and Kevin K. Nguyen and Stefan Vasile and Keith Patrick Choe},
  booktitle={PloS one},
  year={2013}
}
High-throughput screening (HTS) is a powerful approach to drug discovery, but many lead compounds are found to be unsuitable for use in vivo after initial screening. Screening in small animals like C. elegans can help avoid these problems, but this system has been limited to screens with low-throughput or no specific molecular target. We report the first in vivo 1536-well plate assay for a specific genetic pathway in C. elegans. Our assay measures induction of a gene regulated by SKN-1, a… CONTINUE READING

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