An SNP map of human chromosome 22

@article{Mullikin2000AnSM,
  title={An SNP map of human chromosome 22},
  author={James C. Mullikin and Sarah E. Hunt and C. Greifinger J. D. Cole and B. J. Mortimore and Catherine M. Rice and John A Burton and L. Harrison Matthews and Rebecca Pavitt and Robert W. Plumb and Sarah K. Sims and R. M. R. Ainscough and John Attwood and Jacqueline M Bailey and Karen F. Barlow and Richard M. Bruskiewich and Patrick Butcher and Nigel P. Carter and Yixin Chen and Chris Clee and Penny C. Coggill and Joy Davies and Robert S M Davies and Elisabeth Dawson and M. D. Francis and A. A. Joy and Robert Lamble and Cordelia Langford and J. Macarthy and Volker Mall and Amber Moreland and E. K. Overton-Larty and Mark T. Ross and L Courtney Smith and Charles A. Steward and John E. Sulston and E. J. Tinsley and Kevin Turney and David Willey and George D. F. Wilson and Amanda A. McMurray and Ian Dunham and Jane Rogers and D. R. Bentley},
  journal={Nature},
  year={2000},
  volume={407},
  pages={516-520}
}
The human genome sequence will provide a reference for measuring DNA sequence variation in human populations. Sequence variants are responsible for the genetic component of individuality, including complex characteristics such as disease susceptibility and drug response. Most sequence variants are single nucleotide polymorphisms (SNPs), where two alternate bases occur at one position. Comparison of any two genomes reveals around 1 SNP per kilobase. A sufficiently dense map of SNPs would allow… CONTINUE READING

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