An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain.

@article{Poitras2010AnSI,
  title={An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain.},
  author={Luc Poitras and Man Yu and Cindy Lesage-Pelletier and Ryan B Macdonald and Jean-Philippe Gagn{\'e} and Gary T Hatch and Isabelle Kelly and Steven P. Hamilton and John L R Rubenstein and Guy G. Poirier and Marc Ekker},
  journal={Development},
  year={2010},
  volume={137 18},
  pages={3089-97}
}
Dlx homeobox genes play a crucial role in the migration and differentiation of the subpallial precursor cells that give rise to various subtypes of gamma-aminobutyric acid (GABA)-expressing neurons of the forebrain, including local-circuit cortical interneurons. Aberrant development of GABAergic interneurons has been linked to several neurodevelopmental disorders, including epilepsy, schizophrenia, Rett syndrome and autism. Here, we report in mice that a single-nucleotide polymorphism (SNP… CONTINUE READING
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