An SCF-like ubiquitin ligase complex that controls presynaptic differentiation

  title={An SCF-like ubiquitin ligase complex that controls presynaptic differentiation},
  author={Edward H Liao and Wesley Hung and Benjamin S Abrams and Mei Zhen},
During synapse formation, specialized subcellular structures develop at synaptic junctions in a tightly regulated fashion. Cross-signalling initiated by ephrins, Wnts and transforming growth factor-β family members between presynaptic and postsynaptic termini are proposed to govern synapse formation. It is not well understood how multiple signals are integrated and regulated by developing synaptic termini to control synaptic differentiation. Here we report the identification of FSN-1, a novel F… 
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SCF and Cullin/Ring H2-based ubiquitin ligases.
  • R. Deshaies
  • Biology
    Annual review of cell and developmental biology
  • 1999
This review is focused on a conserved ubiquitin ligase complex known as SCF that plays a key role in marking a variety of regulatory proteins for destruction by the 26S proteasome.
Synaptic development is controlled in the periactive zones of Drosophila synapses.
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