An Rrp6-like protein positively regulates noncoding RNA levels and DNA methylation in Arabidopsis.

@article{Zhang2014AnRP,
  title={An Rrp6-like protein positively regulates noncoding RNA levels and DNA methylation in Arabidopsis.},
  author={Huiming Zhang and Kai Tang and Weiqiang Qian and C Duan and Bangshing Wang and Heng Zhen Zhang and Pengcheng Wang and Xiaohong Zhu and Zhaobo Lang and Yu Yang and Jian-Kang Zhu},
  journal={Molecular cell},
  year={2014},
  volume={54 3},
  pages={418-30}
}
Rrp6-mediated nuclear RNA surveillance tunes eukaryotic transcriptomes through noncoding RNA degradation and mRNA quality control, including exosomal RNA decay and transcript retention triggered by defective RNA processing. It is unclear whether Rrp6 can positively regulate noncoding RNAs and whether RNA retention occurs in normal cells. Here we report that AtRRP6L1, an Arabidopsis Rrp6-like protein, controls RNA-directed DNA methylation through positive regulation of noncoding RNAs. Discovered… CONTINUE READING

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