An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.

@article{Ji2004AnRP,
  title={An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.},
  author={Peng Ji and Hong Jiang and Katya Rekhtman and Joanna Bloom and Marina Ichetovkin and Michele Pagano and Liang Zhu},
  journal={Molecular cell},
  year={2004},
  volume={16 1},
  pages={47-58}
}
It is believed that Rb blocks G1-S transition by inhibiting expression of E2F regulated genes. Here, we report that the effects of E2F repression lag behind the onset of G1 cell cycle arrest in timed Rb reexpression experiments. In comparison, kinase inhibitor p27Kip1 protein accumulates with a faster kinetics. Conversely, Rb knockout leads to faster p27 degradation. Rb interacts with the N terminus of Skp2, interferes with Skp2-p27 interaction, and inhibits ubiquitination of p27. Disruption of… CONTINUE READING

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