An RNautophagy/DNautophagy receptor, LAMP2C, possesses an arginine-rich motif that mediates RNA/DNA-binding.

@article{Fujiwara2015AnRR,
  title={An RNautophagy/DNautophagy receptor, LAMP2C, possesses an arginine-rich motif that mediates RNA/DNA-binding.},
  author={Yuuki Fujiwara and Katsunori Hase and Keiji Wada and Tomohiro Kabuta},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={460 2},
  pages={281-6}
}
Lysosomes are sites for the degradation of diverse cellular components. We recently discovered novel lysosomal systems we termed RNautophagy and DNautophagy. In these systems, RNA and DNA, respectively, are directly imported into lysosomes and degraded. A lysosomal membrane protein, LAMP2C was identified as a receptor for these pathways. The short C-terminal cytosolic tail of LAMP2C binds directly to both RNA and DNA. In this study, we examined the mechanisms underlying recognition of nucleic… CONTINUE READING
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