An RNase P RNA subunit mutation affects ribosomal RNA processing.

  title={An RNase P RNA subunit mutation affects ribosomal RNA processing.},
  author={J R Chamberlain and Pag{\'a}n-Ramos and David W. Kindelberger and David Engelke},
  journal={Nucleic acids research},
  volume={24 16},
RNase P is a ribonucleoprotein endoribonuclease responsible for the 5' maturation of precursor tRNAs in all organisms. While analyzing mutations in conserved positions of the yeast nuclear RNase P RNA subunit, significant accumulation of an aberrant RNA of approximately 193 nucleotides was observed. This abundant RNA was identified as a 3'extended form of the 5.8S rRNA. This strain also displays a slightly elevated level of other rRNA processing intermediates with 5-ends at processing site A2… CONTINUE READING


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Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

  • C. F. Evans, D. R. Engelke
  • 1990

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