An RNA pyrophosphohydrolase triggers 5'-exonucleolytic degradation of mRNA in Bacillus subtilis.

@article{Richards2011AnRP,
  title={An RNA pyrophosphohydrolase triggers 5'-exonucleolytic degradation of mRNA in Bacillus subtilis.},
  author={Jamie Richards and Quansheng Liu and Olivier Pellegrini and Helena {\vC}ele{\vs}nik and Shiyi Yao and David H. Bechhofer and Ciar{\'a}n Condon and Joel G. Belasco},
  journal={Molecular cell},
  year={2011},
  volume={43 6},
  pages={
          940-9
        }
}
In Escherichia coli, RNA degradation often begins with conversion of the 5'-terminal triphosphate to a monophosphate, creating a better substrate for internal cleavage by RNase E. Remarkably, no homolog of this key endonuclease is present in many bacterial species, such as Bacillus subtilis and various pathogens. Here, we report that the degradation of primary transcripts in B. subtilis can nevertheless be triggered by an analogous process to generate a short-lived, monophosphorylated… CONTINUE READING

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