An RNA polymerase inhibitor, cyclothiazomycin B1, and its isomer.

  title={An RNA polymerase inhibitor, cyclothiazomycin B1, and its isomer.},
  author={Masaru Hashimoto and Takanori Murakami and Katsuyuki Funahashi and Takashi Tokunaga and Ken-ichi Nihei and Toshikatsu Okuno and Takatsugu Kimura and Hideo Naoki and Hyouta Himeno},
  journal={Bioorganic & medicinal chemistry},
  volume={14 24},
Novel cyclic thiopeptides, cyclothiazomycins B1 (1) and B2 (2), were isolated from Streptomyces sp. A307 as potent hyphal swelling inducing substances. They are stable in the solid state but slowly isomerize with one another in solution. Degradation experiments and spectroscopic analyses disclosed that they comprise unique tricyclic structures each containing a dehydroalanine, and two dehydrohomoalanine residues, along with three thiazolines, three thiazoles, and a trisubstituted pyridine… CONTINUE READING

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