An RNA polymerase II transcription factor shares functional properties with Escherichia coli sigma 70.

@article{Conaway1990AnRP,
  title={An RNA polymerase II transcription factor shares functional properties with Escherichia coli sigma 70.},
  author={Joan W Conaway and Ronald C. Conaway},
  journal={Science},
  year={1990},
  volume={248 4962},
  pages={1550-3}
}
A mammalian transcription factor, which, along with other factors, is essential for accurate initiation of transcription from promoters by RNA polymerase II, has been found to regulate the interaction of polymerase and DNA. This factor, designated beta gamma, drastically reduces the affinity of RNA polymerase II for free DNA containing either promoter or nonpromoter sequences. In this respect, beta gamma functions as does the bacterial transcription initiation factor sigma 70, which expedites… CONTINUE READING
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