An RNA motif advances transcription by preventing Rho-dependent termination.

  title={An RNA motif advances transcription by preventing Rho-dependent termination.},
  author={Anastasia Sevostyanova and Eduardo A. Groisman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 50},
The transcription termination factor Rho associates with most nascent bacterial RNAs as they emerge from RNA polymerase. However, pharmacological inhibition of Rho derepresses only a small fraction of these transcripts. What, then, determines the specificity of Rho-dependent transcription termination? We now report the identification of a Rho-antagonizing RNA element (RARE) that hinders Rho-dependent transcription termination. We establish that RARE traps Rho in an inactive complex but does not… CONTINUE READING


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