An RNA ligand inhibits hepatitis C virus NS3 protease and helicase activities.

  title={An RNA ligand inhibits hepatitis C virus NS3 protease and helicase activities.},
  author={Kotaro Fukuda and Takuya Umehara and Satoru Sekiya and Kikuchi Kunio and Tsunemi Hasegawa and S. Nishikawa},
  journal={Biochemical and biophysical research communications},
  volume={325 3},
The hepatitis C virus non-structural protein 3 (HCV NS3) possesses both protease and helicase activities that are essential for viral replication. In a previous study, we obtained RNA aptamers that specifically and efficiently inhibited NS3 protease activity (G9 aptamers). In order to add helicase-inhibition capability, we attached (U)14 to the 3'-terminal end of a minimized G9 aptamer, DeltaNEO-III. NEO-III-14U was shown to inhibit the NS3 protease activity more efficiently than the original… CONTINUE READING

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