An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3

@article{Sashital2011AnRC,
  title={An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3},
  author={Dipali G. Sashital and M. Jinek and J. Doudna},
  journal={Nature Structural \&Molecular Biology},
  year={2011},
  volume={18},
  pages={680-687}
}
Clustered regularly interspaced short palindromic repeat (CRISPR) chromosomal loci found in prokaryotes provide an adaptive immune system against bacteriophages and plasmids. CRISPR-specific endoRNases produce short RNA molecules (crRNAs) from CRISPR transcripts, which harbor sequences complementary to invasive nucleic acid elements and ensure their selective targeting by CRISPR-associated (Cas) proteins. The extreme sequence divergence of CRISPR-specific endoRNases and their RNA substrates has… Expand
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