An RNA-independent linkage of noncoding transcription to long-range enhancer function.

@article{Yoo2012AnRL,
  title={An RNA-independent linkage of noncoding transcription to long-range enhancer function.},
  author={Eung Jae Yoo and N. E. Cooke and S. A. Liebhaber},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 10},
  pages={
          2020-9
        }
}
The detection of noncoding transcription at multiple enhancers within the mammalian genome raises critical questions regarding whether and how this activity contributes to enhancer function. Here, using in vivo analysis of a human growth hormone (hGH) transgene locus, we report that activation of a domain of noncoding transcription adjacent to the long-range hGH-N enhancer, HSI, is established by the enhancer independent of any interactions with its target promoter. We further demonstrate that… CONTINUE READING

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