An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells.

Abstract

In a diverse group of organisms that includes Caenorhabditis elegans, Drosophila, planaria, hydra, trypanosomes, fungi and plants, the introduction of double-stranded RNAs inhibits gene expression in a sequence-specific manner. These responses, called RNA interference or post-transcriptional gene silencing, may provide anti-viral defence, modulate… (More)

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@article{Hammond2000AnRN, title={An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells.}, author={Scott M. Hammond and Emily Bernstein and David H. Beach and Gregory J. Hannon}, journal={Nature}, year={2000}, volume={404 6775}, pages={293-6} }