An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

@article{Hammond2000AnRN,
  title={An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells},
  author={Scott M. Hammond and Emily Bernstein and David H. Beach and Gregory J. Hannon},
  journal={Nature},
  year={2000},
  volume={404},
  pages={293-296}
}
In a diverse group of organisms that includes Caenorhabditis elegans , Drosophila, planaria, hydra, trypanosomes, fungi and plants, the introduction of double-stranded RNAs inhibits gene expression in a sequence-specific manner. These responses, called RNA interference or post-transcriptional gene silencing, may provide anti-viral defence, modulate transposition or regulate gene expression. We have taken a biochemical approach towards elucidating the mechanisms underlying this genetic… 

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