An RNA-binding chameleon.

  title={An RNA-binding chameleon.},
  author={Colin A. Smith and Val{\'e}rie Calabro and Alan D. Frankel},
  journal={Molecular cell},
  volume={6 5},
The arginine-rich RNA binding motif is found in a wide variety of proteins, including several viral regulatory proteins. Although related at the primary sequence level, arginine-rich domains from different proteins adopt different conformations depending on the RNA site recognized, and in some cases fold only in the context of RNA. Here we show that the RNA binding domain of the Jembrana disease virus (JDV) Tat protein is able to recognize two different TAR RNA sites, from human and bovine… CONTINUE READING


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