An RNA Polymerase II-coupled function for histone H3K36 methylation in checkpoint activation and DSB repair

@article{Jha2014AnRP,
  title={An RNA Polymerase II-coupled function for histone H3K36 methylation in checkpoint activation and DSB repair},
  author={D. Jha and B. Strahl},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={3965 - 3965}
}
Histone modifications are major determinants of DNA double-strand break (DSB) response and repair. Here we elucidate a DSB repair function for transcription-coupled Set2 methylation at H3 lysine 36 (H3K36me). Cells devoid of Set2/H3K36me are hypersensitive to DNA-damaging agents and site-specific DSBs, fail to properly activate the DNA-damage checkpoint, and show genetic interactions with DSB-sensing and repair machinery. Set2/H3K36me3 is enriched at DSBs, and loss of Set2 results in altered… Expand
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References

SHOWING 1-10 OF 74 REFERENCES
Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining
Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
...
1
2
3
4
5
...