An RCS-like retinal dystrophy phenotype in mer knockout mice.

@article{Duncan2003AnRR,
  title={An RCS-like retinal dystrophy phenotype in mer knockout mice.},
  author={Jacque L Duncan and Matthew M. Lavail and Douglas Yasumura and Michael Matthes and Haidong Yang and Nikolaus Trautmann and Aimee V. Chappelow and Wei Feng and H Shelton Earp and Glenn K. Matsushima and Douglas Vollrath},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 2},
  pages={826-38}
}
PURPOSE To determine whether mice that are homozygous for a targeted disruption of the Mer receptor tyrosine kinase gene (mer(kd)) manifest a retinal dystrophy phenotype similar to RCS rats, which carry a mutation in the orthologous gene MERTK: METHODS Eyes of mer(kd) and C57BL/6 wild-type (WT) mice were examined by light and electron microscopy, whole-eye rhodopsin measurement, and Ganzfeld electroretinography (ERG). RESULTS The mer(kd) mice showed rapid, progressive degeneration of the… CONTINUE READING

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