An RBP4 promoter polymorphism increases risk of type 2 diabetes

  title={An RBP4 promoter polymorphism increases risk of type 2 diabetes},
  author={Mandy van Hoek and Abbas Dehghan and M C Carola Zillikens and Albert Hofman and Jacqueline C. M. Witteman and Eric J G Sijbrands},
  pages={1423 - 1428}
Retinol-binding protein 4 (RBP4), originally known for retinol transport, was recently identified as an adipokine affecting insulin resistance. The RBP4 −803GA promoter polymorphism influences binding of hepatic nuclear factor 1α and is associated with type 2 diabetes in case–control studies. We hypothesised that the RBP4 −803GA polymorphism increases type 2 diabetes risk at a population-based level. In addition, information on retinol intake and plasma vitamin A levels enabled us to explore… CONTINUE READING


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Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2007
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