An Overview of the Direct Thrombin Inhibitor Argatroban

  title={An Overview of the Direct Thrombin Inhibitor Argatroban},
  author={Jeanine M. Walenga},
  journal={Pathophysiology of haemostasis and thrombosis},
  volume={32 Suppl 3},
Argatroban is a small molecule direct thrombin inhibitor. The main attributes of this synthetic drug are its rapid onset of anti-thrombin action, rapid reversibility of its anticoagulant effect, potent inhibition of clot-bound thrombin, absence of antibody formation and no need for initial dosage adjustment in patients with renal impairment. It is eliminated by hepatic metabolism. These properties make argatroban a predictable anticoagulant with intravenous use in a routine clinical setting… CONTINUE READING


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