An Overview of the Advantages of KEAP1-NRF2 System Activation During Inflammatory Disease Treatment.

@article{KelekuLukwete2018AnOO,
  title={An Overview of the Advantages of KEAP1-NRF2 System Activation During Inflammatory Disease Treatment.},
  author={Nadine Keleku-Lukwete and Mikiko Suzuki and Masayuki Yamamoto},
  journal={Antioxidants & redox signaling},
  year={2018},
  volume={29 17},
  pages={
          1746-1755
        }
}
SIGNIFICANCE Inflammation can be defined as a protective immune response against harmful exogenous and endogenous stimuli. Nevertheless, prolonged or autoimmune inflammatory responses are likely to cause pathological states that are associated with a production of inflammation-associated molecules along with reactive oxygen species (ROS). Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (KEAP1-NRF2) signaling provides a cell protection mechanism against oxidative… CONTINUE READING
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