An Overexpression Screen of Toxoplasma gondii Rab-GTPases Reveals Distinct Transport Routes to the Micronemes

@inproceedings{Kremer2013AnOS,
  title={An Overexpression Screen of Toxoplasma gondii Rab-GTPases Reveals Distinct Transport Routes to the Micronemes},
  author={Katrin Kremer and Dirk Kamin and Eva Rittweger and Jonathan Wilkes and Halley P Flammer and S. Graciela Mahler and Joanne Heng and Christopher J. Tonkin and Gordon Langsley and Stefan W Hell and Vernon B. Carruthers and David J. P. Ferguson and Markus Meissner},
  booktitle={PLoS pathogens},
  year={2013}
}
The basic organisation of the endomembrane system is conserved in all eukaryotes and comparative genome analyses provides compelling evidence that the endomembrane system of the last common eukaryotic ancestor (LCEA) is complex with many genes required for regulated traffic being present. Although apicomplexan parasites, causative agents of severe human and animal diseases, appear to have only a basic set of trafficking factors such as Rab-GTPases, they evolved unique secretory organelles… CONTINUE READING
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Comparative genomics of the Rab protein family in Apicomplexan parasites

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