An Over Expression APP Model for Anti-Alzheimer Disease Drug Screening Created by Zinc Finger Nuclease Technology

Abstract

Zinc Finger Nucleases (ZFNs), famous for their ability to precisely and efficiently modify specific genomic loci, have been employed in numerous transgenic model organism and cell constructions. Here we employ the ZFNs technology, with homologous recombination (HR), to construct sequence-specific Amyloid Precursor Protein (APP) knock-in cells. With the use… (More)
DOI: 10.1371/journal.pone.0075493

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@inproceedings{Zhang2013AnOE, title={An Over Expression APP Model for Anti-Alzheimer Disease Drug Screening Created by Zinc Finger Nuclease Technology}, author={Xiaojing Zhang and Hui Li and Yiqing Mao and Zhixin Li and Rong Wang and Tingting Guo and Ling Jin and Rongjing Song and Wei Xu and Na Zhou and Yizhuang Zhang and Ruobi Hu and Xi Wang and Huakang Huang and Zhen Lei and Gang Niu and David M. Irwin and Huanran Tan}, booktitle={PloS one}, year={2013} }