An Oral Supplementation Based on Hydrolyzed Collagen and Vitamins Improves Skin Elasticity and Dermis Echogenicity: A Clinical Placebo- Controlled Study

  title={An Oral Supplementation Based on Hydrolyzed Collagen and Vitamins Improves Skin Elasticity and Dermis Echogenicity: A Clinical Placebo- Controlled Study},
  author={Patr{\'i}cia Maia Campos Mbg and Ma{\'i}sa Oliveira de Melo and L{\'i}via Salom{\~a}o Calixto and M Fossa},
  journal={Clinical Pharmacology \& Biopharmaceutics},
The aim of this study was to evaluate the clinical efficacy of an oral supplementation based on hydrolyzed collagen and vitamins in the improvement of aged skin conditions using biophysical and skin imaging techniques. In this doubleblind, placebo-controlled trials, 60 woman aged between 40-60 years were randomized to receive the product containing hydrolyzed collagen and vitamins (Group A) or the placebo (Group B), once daily for 90-days period. Skin elasticity, dermis echogenicity, hydration… 

Figures and Tables from this paper

Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta‐analysis
Based on results, ingestion of hydrolyzed collagen for 90 days is effective in reducing skin aging, as it reduces wrinkles and improves skin elasticity and hydration.
Beneficial effects of food supplements based on hydrolyzed collagen for skin care (Review)
An update on the use of hydrolyzed collagen for skin care is presented, demonstrating that peptides resulted from ingestion of hydrolysate collagen and detected in the blood stream have chemotactic properties for skin fibroblasts, helping the skin restoration process.
Bioactivity and Tablet Formulation from Spirulina and Collagen Hydrolysate of Tilapia (Oreochromis niloticus) Skin
Spirulina is a microalga known as a superfood which contains high protein and is used in cosmetics, foods, and supplements industry. Collagen hydrolysate is the result of hydrolysis of collagen by
Application of biophysical and skin imaging techniques to evaluate the film‐forming effect of cosmetic formulations
Products with film‐forming effect, or ‘second skin’, which guarantees an immediate protective effect after application, is a highlight, especially when composed of natural ingredients. Thus, the
Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails
In women with brittle nail syndrome, nails that exhibit surface roughness, raggedness, and peeling are a common problem and treatment is needed to correct the problem.
Collagen: From Waste to Gold
This chapter presents a waste valorisation opportunity to extract collagen from waste bovine hide off-cuttings and discusses collagen extraction method optimization and methods used to investigate physicochemical properties of collagen.
A Review on the Quality Control Analysis of Oral Dosage Form: Tablets
In this review article tablet evaluation techniques and methods have been explained which are applicable to all the dosage forms production.
Photoageing‐related skin changes in different age groups: a clinical evaluation by biophysical and imaging techniques
Evaluated the photoageing‐related changes in the skin of different age groups by biophysical and imaging techniques to assess morphological and structural changes caused by solar radiation in young people.
Extraction and characterization of collagen from bovine hides for preparation of biodegradable films
................................................................................................................... ii Acknowledgements
Tablets Manufacturing Methods and Granulation Techniques
From past hundred years tablet manufacturers have developed materials and processes that can produce compressed tablets containing a precise amount of an active pharmaceutical ingredient (API) at


Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study
After 4 weeks of follow-up treatment, a statistically significantly higher skin elasticity level was determined in elderly women, and a positive influence of CH treatment could be observed in a subgroup analysis, but data failed to reach a level of statistical significance.
Effects of a nutritional supplement containing collagen peptides on skin elasticity, hydration and wrinkles
This study shows that the oral nutritional supplement consisting of hydrolyzed collagen, hyaluronic acid, and essential vitamins and minerals, leads to a significant improvement in wrinkle depth and can induce noticeable improvement in elasticity and hydration of the skin.
Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis
The findings demonstrate that the oral intake of specific bioactive collagen peptides (Verisol®) reduced skin wrinkles and had positive effects on dermal matrix synthesis.
An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies
Hydlysed collagen, an increasingly popular nutraceutical, is composed of low molecular weight small peptides, which are easily digestible, absorbed and distributed in the human body and can be considered an important weapon in the everyday fight against skin ageing.
A new view concerning the effects of collagen hydrolysate intake on skin properties
  • V. Zague
  • Biology
    Archives of Dermatological Research
  • 2008
To comprehensively study the different benefits of CH on skin, controlled clinical trials are needed in addition to the previous pre-clinical and bioavailability assays.
Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin.
Effect of a novel dietary supplement on skin aging in post-menopausal women
This novel dietary supplement, Imedeen Prime Renewal™, provides improved condition, structure and firmness of the skin in post-menopausal women after 6 months.
Efficacy Evaluation of a Multifunctional Cosmetic Formulation: The Benefits of a Combination of Active Antioxidant Substances
The multifunctional cosmetic formulation studied can be suggested to preventing signs of aging and improving skin conditions by associating different active antioxidants substances in a single cosmetic formulation to prevent skin aging.
Evaluation of the photoprotective effect of oral vitamin E supplementation.
Daily ingestion of 400 IU of oral alpha-tocopherol daily does not provide meaningful photoprotection and no clinical or histologic difference in the response to UVB could be detected between the placebo and vitamin E-supplemented groups.
Rheology, clinical efficacy and sensorial of a silicone-based formulation containing pearl extract
It is suggested that the silicone-based formulation supplemented with the pearl extract could combine unique sensory properties and effectiveness to better meet consumer’s demand.