An Open-Label Study of Controlled-Release Melatonin in Treatment of Sleep Disorders in Children with Autism

@article{Giannotti2006AnOS,
  title={An Open-Label Study of Controlled-Release Melatonin in Treatment of Sleep Disorders in Children with Autism},
  author={F. Giannotti and F. Cortesi and A. Cerquiglini and P. Bernabei},
  journal={Journal of Autism and Developmental Disorders},
  year={2006},
  volume={36},
  pages={741-752}
}
Long-term effectiveness of controlled-release melatonin in 25 children, aged 2.6–9.6 years with autism without other coexistent pathologies was evaluated openly. Sleep patterns were studied using Children’s Sleep Habits Questionnaire (CSHQ) and sleep diaries at baseline, after 1–3–6 months melatonin treatment and 1 month after discontinuation. Sleep diary and CSHQ showed a more problematic sleep in autistic children compared with controls. During treatment sleep patterns of all children… Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Clinical trials of controlled‐release melatonin in children with sleep–wake cycle disorders
TLDR
The studies showed that the FR melatonin was most effective when there was only delayed sleep onset, but CR formulations were more useful for sleep maintenance, and children appeared to require higher doses than adults. Expand
Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial.
TLDR
Melatonin improves health status and advances the sleep-wake rhythm in children with idiopathic chronic sleep-onset insomnia. Expand
Effectiveness of melatonin in the treatment of sleep disturbances in children with Asperger disorder.
TLDR
Melatonin may provide an interesting new and well-tolerated treatment option for children with Asperger disorder suffering from chronic insomnia, however, these results must be confirmed in a controlled study. Expand
Improvement of sleep quality by controlled-release melatonin in benzodiazepine-treated elderly insomniacs.
TLDR
Melatonin replacement therapy can improve sleep quality in the elderly and that the beneficial effects are augmented in the presence of benzodiazepines, as compared to placebo. Expand
Effects of a Low Dose of Melatonin on Sleep in Children with Angelman Syndrome
TLDR
The data suggest that a moderate increase in circulating melatonin levels significantly reduces motor activity during the sleep period in Angelman syndrome children, and promotes sleep. Expand
Melatonin treatment for sleep disorders in children with neurodevelopmental disorders: an observational study.
TLDR
The study aim was to quantify melatonin-associated improvement in sleep by means of a parent-completed sleep diary during routine outpatient activity and found that 34 patients who were assessed showed an improvement. Expand
Use of melatonin in the treatment of paediatric sleep disorders
TLDR
Melatonin appears to be a safe, inexpensive, and a very effective treatment of sleep‐wake cycle disorders in children with disabilities, especially since multidisabled children with chronic sleep difficulties do not respond well to current therapeutic regimes. Expand
Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment
TLDR
While the variability of individual responsiveness was high, melatonin appeared to improve total sleep time and sleep efficiency in the patients with the worse baseline sleep quality, and a 4‐week administration of melatonin appears to be a safe treatment. Expand
Melatonin for the treatment of sleep disturbances in major depressive disorder.
TLDR
Slow-release melatonin was effective in improving the sleep of patients with major depressive disorder and had no effect on the rate of improvement in symptoms ofmajor depressive disorder. Expand
Long‐term melatonin treatment in blind children and young adults with circadian sleep‐wake disturbances
TLDR
Oral melatonin therapy was used to treat severe circadian sleep‐wake disturbances in eight children and young adults in an open study, promising as an efficient and seemingly safe alternative for treatment of severe circadianSleep disturbances. Expand
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