An Open-Label, Single-Dose, Crossover Study of the Pharmacokinetics and Metabolism of Two Oral Formulations of 1-Octanol in Patients with Essential Tremor

@article{Nahab2011AnOS,
  title={An Open-Label, Single-Dose, Crossover Study of the Pharmacokinetics and Metabolism of Two Oral Formulations of 1-Octanol in Patients with Essential Tremor},
  author={Fatta B. Nahab and Loretta Wittevrongel and Dominic Ippolito and Camilo Toro and George J Grimes and Judith M Starling and Gopal K. Potti and Dietrich Haubenberger and Daniel Bowen and Peter Buchwald and Chuanhui Dong and Daniel Kalowitz and Mark Hallett},
  journal={Neurotherapeutics},
  year={2011},
  volume={8},
  pages={753-762}
}
Existing therapeutic options for management of essential tremor are frequently limited by poor efficacy and adverse effects. Likely the most potent tremor suppressant used is ethanol, although its use is prohibitive due to a brief therapeutic window, and the obvious implications of excessive alcohol use. Longer-chain alcohols have been shown to suppress tremor in harmaline animal models, and appear to be safe and well tolerated in 2 prior studies in humans. Here we report on the findings of a… Expand
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