An Oncogene-Induced DNA Damage Model for Cancer Development

@article{Halazonetis2008AnOD,
  title={An Oncogene-Induced DNA Damage Model for Cancer Development},
  author={Thanos D Halazonetis and Vassilis G. Gorgoulis and Jiri Bartek},
  journal={Science},
  year={2008},
  volume={319},
  pages={1352 - 1355}
}
Of all types of DNA damage, DNA double-strand breaks (DSBs) pose the greatest challenge to cells. One might have, therefore, anticipated that a sizable number of DNA DSBs would be incompatible with cell proliferation. Yet recent experimental findings suggest that, in both precancerous lesions and cancers, activated oncogenes induce stalling and collapse of DNA replication forks, which in turn leads to formation of DNA DSBs. This continuous formation of DNA DSBs may contribute to the genomic… Expand
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