An Octopamine-Mushroom Body Circuit Modulates the Formation of Anesthesia-Resistant Memory in Drosophila

@article{Wu2013AnOB,
  title={An Octopamine-Mushroom Body Circuit Modulates the Formation of Anesthesia-Resistant Memory in Drosophila},
  author={Chia-Lin Wu and Meng-Fu Maxwell Shih and Pei-Tseng Lee and A. M. Chiang},
  journal={Current Biology},
  year={2013},
  volume={23},
  pages={2346-2354}
}
BACKGROUND Drosophila olfactory aversive conditioning produces two components of intermediate-term memory: anesthesia-sensitive memory (ASM) and anesthesia-resistant memory (ARM). Recently, the anterior paired lateral (APL) neuron innervating the whole mushroom body (MB) has been shown to modulate ASM via gap-junctional communication in olfactory conditioning. Octopamine (OA), an invertebrate analog of norepinephrine, is involved in appetitive conditioning, but its role in aversive memory… CONTINUE READING
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