An Observational Study of Blood Concentrations and Kinetics of Methyl- and Propyl-Parabens in Neonates

@article{Mulla2014AnOS,
  title={An Observational Study of Blood Concentrations and Kinetics of Methyl- and Propyl-Parabens in Neonates},
  author={Hussain Mulla and Shirish Yakkundi and James C McElnay and Irja Lutsar and Tuuli Metsvaht and Heili Varendi and Georgi Nellis and A A Nunn and Jacque Duncan and Hitesh Pandya and Mark Turner},
  journal={Pharmaceutical Research},
  year={2014},
  volume={32},
  pages={1084-1093}
}
Systemic exposure to parabens in the neonatal population, in particular propyl-parabens (PPB), remains a concern. Blood concentrations and kinetics of methyl-parabens (MPB) and PPB were therefore determined in neonates receiving medicines containing these excipients. A multi-centre, non-interventional, observational study of excipient-kinetics in neonates. ‘Dried Blood Spot’ samples were collected opportunistically at the same time as routine samples and the observations modelled using a non… CONTINUE READING