An OHSS-Free Clinic by segmentation of IVF treatment.

@article{Devroey2011AnOC,
  title={An OHSS-Free Clinic by segmentation of IVF treatment.},
  author={P. Devroey and N. Polyzos and C. Blockeel},
  journal={Human reproduction},
  year={2011},
  volume={26 10},
  pages={
          2593-7
        }
}
Published data indicate a significant increase in ovarian hyperstimulation syndrome globally. The occurrence of approximately three maternal deaths per 100,000 stimulated women has been reported, and extrapolation of these figures to a global situation would give an impressive number. The syndrome can be erased by applying ovarian stimulation using the combination of GnRH antagonist with GnRH agonist to trigger ovulation. In this case, the strategy is to freeze all of the oocytes or embryos for… Expand
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References

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OHSS Free Clinic
If ovarian stimulation is performed accordingly to new strategies available, the occurrence of ovarian hyperstimulation syndrome will be eradicated. The strategy is to stimulate all women with GnRHExpand
Avoiding the use of human chorionic gonadotropin combined with oocyte vitrification and GnRH agonist triggering versus coasting: a new strategy to avoid ovarian hyperstimulation syndrome.
TLDR
Results show that oocyte vitrification after GnRH agonists triggering is a highly attractive, safe, and efficient alternative to postpone embryo transfer in patients at high risk of OHSS, resulting in decreased risk for the patient and a better cycle outcome. Expand
Obstetric outcome of in vitro fertilized pregnancies complicated by severe ovarian hyperstimulation syndrome: a multicenter study.
TLDR
Among patients who have severe OHSS after IVF treatment, the pregnancy rate and the rates of multiple gestation, miscarriage, prematurity, low birth weight, pregnancy-induced hypertension, gestational diabetes, and placental abruption are significantly higher than those reported previously for pregnancies conceived with the use of assisted reproductive techniques. Expand
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TLDR
It is suggested that elective cryopreservation of all zygotes might prevent the risk of OHSS in patients undergoing IVF treatment, and the results show that the elective Cryop Reservation of zygote does not affect pregnancy and live birth rates. Expand
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TLDR
It is suggested that moderated hCG dosage is useful in preventing OHSS without reducing efficacy and the probabilities of embryo transfer, implantation, or clinical pregnancy. Expand
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TLDR
Polycystic ovary syndrome may be considered to be a risk factor for OHSS with an evidence level II, however, for other risk factors, only evidence level III could be reached. Expand
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TLDR
The early OHSS pattern is associated with exogenously administered HCG and a higher risk of preclinical miscarriage, whereas late OHSS may be closely associated with the conception cycles, especially multiple pregnancies, and is more likely to be severe. Expand
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TLDR
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Treatment with the GnRH antagonist ganirelix prevents premature LH rises and luteinization in stimulated intrauterine insemination: results of a double-blind, placebo-controlled, multicentre trial.
TLDR
Treatment with ganirelix effectively prevents premature LH rises, luteinization in subjects undergoing stimulated IUI and low-dose rFSH regimen combined with a GnRH antagonist may be an alternative treatment option for subjects with previous proven lute inization or in subjects who would otherwise require insemination when staff are not working. Expand
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TLDR
The present study is the proof of the concept that GnRH-agonist triggering of final oocyte maturation in combination with elective cryopreservation of 2 PN oocytes offers OHSS risk patients a good chance of pregnancy achievement, while reducing the risk of moderate and severe OHSS. Expand
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