An OGG1 polymorphism is associated with mitochondrial DNA content in pesticide-exposed fruit growers.

@article{Huang2011AnOP,
  title={An OGG1 polymorphism is associated with mitochondrial DNA content in pesticide-exposed fruit growers.},
  author={Pei-Lin Huang and Ming-Fuu Wang and H Lee and Yi-jie Liu and Chun-Chieh Chen and S Chen and J Lai and Ruey-Hong Wong},
  journal={Toxicology},
  year={2011},
  volume={287 1-3},
  pages={8-14}
}
Exposure to pesticides has the capacity to cause mitochondrial dysfunction. An increase mitochondrial DNA (mtDNA) content has also been suggested to relate with DNA damaging agent. In mitochondria, the manganese superoxide dismutase (MnSOD) is a scavenger of reactive oxygen species, and the 8-oxoguanine DNA glycosylase (OGG1) is the major DNA glycosylase for the repair of 8-oxoG lesions. However, the alteration of mtDNA content elicited by pesticide exposure in people with genetic variations in… CONTINUE READING