An OGG1 orthologue encoding a functional 8-oxoguanine DNA glycosylase/lyase in Arabidopsis thaliana

@article{GarcaOrtz2001AnOO,
  title={An OGG1 orthologue encoding a functional 8-oxoguanine DNA glycosylase/lyase in Arabidopsis thaliana},
  author={Mar{\'i}a-Victoria Garc{\'i}a-Ort{\'i}z and Rafael R Ariza and Teresa Rold{\'a}n-Arjona},
  journal={Plant Molecular Biology},
  year={2001},
  volume={47},
  pages={795-804}
}
Repair of the ubiquitous mutagenic lesion 7,8-dihydro-8-oxoguanine (8-oxoG) is initiated in eukaryotes by DNA glycosylases/lyases, such as yeast Ogg1, that do not share significant sequence identity with their prokaryotic counterparts, typified by Escherichia coli MutM (Fpg) protein. The unexpected presence of a functional mutM orthologue in the model plant Arabidopsis thaliana has brought into question the existence of functional OGG1 orthologues in plants. We report here the cDNA cloning… CONTINUE READING

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Cloning and characterization of mammalian 8 - hydroxyguanine - specific DNA glycosylase / apurinic , apyrim - idinic lyase , a functional MutM homolog

  • S. F. Altschul, T. L. Madden, +4 authors D. J. Lipman
  • 1997
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