An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation

@article{Prall2007AnNN,
  title={An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation},
  author={Owen W.J. Prall and M. K. C. Menon and Mark J. Solloway and Yusuke Watanabe and St{\'e}phane Zaffran and Fanny Bajolle and Christine Biben and Jim J. McBride and Bronwyn R. Robertson and Herv{\'e} Chaulet and Fiona A. Stennard and Natalie Wise and Daniel Schaft and Orit Wolstein and Milena B. Furtado and Hidetaka Shiratori and Kenneth R. Chien and Hiroshi Hamada and Brian L Black and Yumiko Saga and Elizabeth J Robertson and Margaret E. Buckingham and Richard P. Harvey},
  journal={Cell},
  year={2007},
  volume={128},
  pages={947-959}
}
During heart development the second heart field (SHF) provides progenitor cells for most cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now show that feedback repression of Bmp2/Smad1 signaling by Nkx2-5 critically regulates SHF proliferation and outflow tract (OFT) morphology. In the cardiac fields of Nkx2-5 mutants, genes controlling… CONTINUE READING