An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors.

@article{Brimecombe1998AnNP,
  title={An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors.},
  author={J C Brimecombe and Mark J Gallagher and David R Lynch and Elias Aizenman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={286 2},
  pages={
          627-34
        }
}
Haloperidol and ifenprodil are N-methyl-D-aspartate (NMDA) receptor (NR) antagonists with preference for the NR1/NR2B subunit combination. Previous investigations utilizing 125I-MK801 binding assays with recombinant receptors distinguished certain structural determinants on the NR2B subunit for these two drugs, with glutamate 201 being critical for haloperidol sensitivity and arginine 337 being important for ifenprodil block. Other studies, however, suggested that these two sites… CONTINUE READING

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