An NMDA antagonist (LY 235959) attenuates abstinence-induced withdrawal of planarians following acute exposure to a cannabinoid agonist (WIN 52212-2)

@article{Rawls2007AnNA,
  title={An NMDA antagonist (LY 235959) attenuates abstinence-induced withdrawal of planarians following acute exposure to a cannabinoid agonist (WIN 52212-2)},
  author={Scott M. Rawls and Teresa Ortiz G{\'o}mez and Robert B Raffa},
  journal={Pharmacology Biochemistry and Behavior},
  year={2007},
  volume={86},
  pages={499-504}
}
The mechanisms that facilitate the development and expression of cannabinoid physical dependence in humans and other mammals are poorly understood. The present experiments used a planarian model to provide evidence that pharmacological antagonism of NMDA receptors significantly attenuates the development of cannabinoid physical dependence. Abstinence-induced withdrawal from the cannabinoid agonist WIN 55212-2 (10 microM) was manifested as a significant (P<0.05) decrease in the rate of planarian… CONTINUE READING

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