An NGR-integrated and enediyne-energized apoprotein shows CD13-targeting antitumor activity.

Abstract

Targeting and inhibiting angiogenesis is a promising strategy for treatment of cancer. NGR peptide motif is a tumor-homing peptide, which could bind with CD13 expressed on tumor blood vessels. Lidamycin is a highly potent antitumor antibiotic, which is composed of an apoprotein (LDP) and an active enediyne chromophore (AE). Here, an NGR-integrated and… (More)
DOI: 10.1016/j.biopha.2012.10.018

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