An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons.

@article{Riccio1997AnNR,
  title={An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons.},
  author={Antonella Riccio and Brian A Pierchala and C L Ciarallo and David D Ginty},
  journal={Science},
  year={1997},
  volume={277 5329},
  pages={1097-100}
}
Nerve growth factor (NGF) is a neurotrophic factor secreted by cells that are the targets of innervation of sympathetic and some sensory neurons. However, the mechanism by which the NGF signal is propagated from the axon terminal to the cell body, which can be more than 1 meter away, to influence biochemical events critical for growth and survival of neurons has remained unclear. An NGF-mediated signal transmitted from the terminals and distal axons of cultured rat sympathetic neurons to their… CONTINUE READING
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