An N-terminal domain of adenovirus protein VI fragments membranes by inducing positive membrane curvature.

@article{Maier2010AnND,
  title={An N-terminal domain of adenovirus protein VI fragments membranes by inducing positive membrane curvature.},
  author={Oana Maier and Debra L Galan and Harald Wodrich and Christopher M. Wiethoff},
  journal={Virology},
  year={2010},
  volume={402 1},
  pages={11-9}
}
Adenovirus (Ad) membrane penetration during cell entry is poorly understood. Here we show that antibodies which neutralize the membrane lytic activity of the Ad capsid protein VI interfere with Ad endosomal membrane penetration. In vitro studies using a peptide corresponding to an N-terminal amphipathic alpha-helix of protein VI (VI-Phi), as well as other truncated forms of protein VI suggest that VI-Phi is largely responsible for protein VI binding to and lysing of membranes. Additional… CONTINUE READING

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