An MboI two-allele polymorphism may implicate the human renin gene in primary hypertension.

@article{Frossard1998AnMT,
  title={An MboI two-allele polymorphism may implicate the human renin gene in primary hypertension.},
  author={Philippe M. Frossard and Gilles G. Lestringant and Y I Elshahat and Anne John and Enyioma N. Obineche},
  journal={Hypertension research : official journal of the Japanese Society of Hypertension},
  year={1998},
  volume={21 3},
  pages={221-5}
}
As a key enzyme of the renin-angiotensin-aldosterone system, the renin gene (REN) is a good candidate quantitative trait locus that may be implicated in the molecular etiology of essential hypertension. Among mixed reports on the subject, a REN MboI restriction fragment length polymorphism has been shown to be significantly associated with a family history of hypertension in a Japanese population. We show here that the REN MboI dimorphic site is located in the ninth intron of the gene, and we… CONTINUE READING
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