An MRI-based index to measure the severity of Alzheimer's disease-like structural pattern in subjects with mild cognitive impairment.

@article{Spulber2013AnMI,
  title={An MRI-based index to measure the severity of Alzheimer's disease-like structural pattern in subjects with mild cognitive impairment.},
  author={Gabriela Spulber and Andrew Simmons and J-S Muehlboeck and Patrizia Mecocci and Bruno Vellas and Magda Tsolaki and Iwona Kłoszewska and Hilkka Soininen and Christian Spenger and Simon Lovestone and Lars-Olof Wahlund and Eric Westman},
  journal={Journal of internal medicine},
  year={2013},
  volume={273 4},
  pages={396-409}
}
BACKGROUND Structural magnetic resonance imaging (MRI) is sensitive to neurodegeneration and can be used to estimate the risk of converting to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). Brain changes in AD and prodromal AD involve a pattern of widespread atrophy. The use of multivariate analysis algorithms could enable the development of diagnostic tools based on structural MRI data. In this study, we investigated the possibility of combining multiple MRI… CONTINUE READING

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