An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses.

@article{Hu2017AnMC,
  title={An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses.},
  author={Yanmei Hu and Rami Ghassan Musharrafieh and Chunlong Ma and Jiantao Zhang and Donald F. Smee and William F. DeGrado and Jun Wang},
  journal={Antiviral research},
  year={2017},
  volume={140},
  pages={45-54}
}
Adamantanes such as amantadine (1) and rimantadine (2) are FDA-approved anti-influenza drugs that act by inhibiting the wild-type M2 proton channel from influenza A viruses, thereby inhibiting the uncoating of the virus. Although adamantanes have been successfully used for more than four decades, their efficacy was curtailed by emerging drug resistance. Among the limited number of M2 mutants that confer amantadine resistance, the M2-V27A mutant was found to be the predominant mutant under drug… CONTINUE READING
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