An Lc-ms/ms Method for the Quantification of Memantine in Human Plasma: Development, Validation and Application to a Pharmacokinetic Study

Abstract

Memantine hydrochloride (MMH), 1-amino-3, 5 dimethyladamantane hydrochloride, is an adamantine derivative administered orally for many neurologic disorders, including Alzheimer’s disease. A rapid, simple, sensitive and specific liquid chromatography-tandem mass spectrometry method was developed for the estimation of memantine in human plasma. Sample… (More)

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@inproceedings{Karthikeyan2013AnLM, title={An Lc-ms/ms Method for the Quantification of Memantine in Human Plasma: Development, Validation and Application to a Pharmacokinetic Study}, author={Sarita Karthikeyan and Anju Aji and Sarabjit Singh and Shivanand P. Puthli}, year={2013} }