An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro

@article{Billiar1989AnLM,
  title={An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro},
  author={T Billiar and R D Curran and DJ Stuehr and M R West and BG Bentz and R Simmons},
  journal={The Journal of Experimental Medicine},
  year={1989},
  volume={169},
  pages={1467 - 1472}
}
The hepatic failure associated with severe sepsis is characterized by specific, progressive, and often irreversible defects in hepatocellular metabolism (1). Although the etiologic microbe can often be identified, the direct causes and mechanisms of the hepatocellular dysfunction are poorly understood. We have hypothesized that Kupffer cells (KC), which interact with ambient septic stimuli, respond by providing signals to adjacent hepatocytes (HC) in sepsis . Furthermore, we have provided… CONTINUE READING
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