An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron

@article{Mckie2001AnIF,
  title={An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron},
  author={A. Mckie and D. Barrow and G. Latunde-Dada and A. Rolfs and G. Sager and E. Mudaly and M. Mudaly and C. Richardson and D. Barlow and A. Bomford and T. Peters and K. Raja and S. Shirali and M. Hediger and F. Farzaneh and R. Simpson},
  journal={Science},
  year={2001},
  volume={291},
  pages={1755 - 1759}
}
The ability of intestinal mucosa to absorb dietary ferric iron is attributed to the presence of a brush-border membrane reductase activity that displays adaptive responses to iron status. We have isolated a complementary DNA, Dcytb (for duodenal cytochrome b), which encoded a putative plasma membrane di-heme protein in mouse duodenal mucosa. Dcytb shared between 45 and 50% similarity to the cytochrome b561 family of plasma membrane reductases, was highly expressed in the brush-border membrane… Expand

Paper Mentions

Interventional Clinical Trial
The goal of our research is to provide data to enhance the development of nutritional guidelines, especially as related to mineral nutrition, in children. Using human… Expand
ConditionsMineral Absorption
InterventionDietary Supplement
Identification of an Intestinal Heme Transporter
The role of Dcytb in iron metabolism: an update.
  • A. Mckie
  • Biology, Medicine
  • Biochemical Society transactions
  • 2008
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